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IL-27 enhances the survival of tumor antigen-specific CD8(+) T cells and programs them into IL-10-producing, memory precursor-like effector cells

IL-27 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3), and a p35-related subunit, p28. IL-27 functions through IL-27R and has been shown to have potent anti-tumor activity via activation of a variety of cellular compon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Zhenzhen, Liu, Jin-Qing, Talebian, Fatemeh, Wu, Lai-Chu, Li, Shulin, Bai, Xue-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625660/
https://ncbi.nlm.nih.gov/pubmed/23225163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242930
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