Rapid Screening of Drug-Protein Binding Using High-Performance Affinity Chromatography with Columns Containing Immobilized Human Serum Albumin

For drug candidates, a plasma protein binding (PPB) more than 90% is more meaningful and deserves further investigation in development. In the study, a high-performance liquid chromatography method employing column containing immobilized human serum albumin (HSA) to screen in vitro PPB of leading co...

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Detalhes bibliográficos
Main Authors: Li, Ying-Fei, Zhang, Xiao-Qiong, Hu, Wei-Yu, Li, Zheng, Liu, Ping-Xia, Zhang, Zhen-Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625562/
https://ncbi.nlm.nih.gov/pubmed/23607050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/439039
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