Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii

Toxoplasma gondii is sensitive to bulky pyrazolo [3,4-d] pyrimidine (PP) inhibitors due to the presence of a Gly gatekeeper in the essential calcium dependent protein kinase 1 (CDPK1). Here we synthesized a number of new derivatives of 3-methyl-benzyl-PP (3-MB-PP, or 1). The potency of PP analogs in...

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Autori principali: Lourido, Sebastian, Zhang, Chao, Lopez, Michael, Tang, Keliang, Barks, Jennifer, Wang, Qiuling, Wildman, Scott A., Shokat, Kevan M., Sibley, L. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625458/
https://ncbi.nlm.nih.gov/pubmed/23470217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4001314
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