Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here, by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defense mechanisms in humans. Candi...

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Main Authors: Smeekens, Sanne P., Ng, Aylwin, Kumar, Vinod, Johnson, Melissa D., Plantinga, Theo S., van Diemen, Cleo, Arts, Peer, Verwiel, Eugéne T.P., Gresnigt, Mark S., Fransen, Karin, van Sommeren, Suzanne, Oosting, Marije, Cheng, Shih-Chin, Joosten, Leo A.B., Hoischen, Alexander, Kullberg, Bart-Jan, Scott, William K., Perfect, John R., van der Meer, Jos W.M., Wijmenga, Cisca, Netea, Mihai G., Xavier, Ramnik J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625375/
https://ncbi.nlm.nih.gov/pubmed/23299892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2343
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