Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here, by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defense mechanisms in humans. Candi...

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Autori principali: Smeekens, Sanne P., Ng, Aylwin, Kumar, Vinod, Johnson, Melissa D., Plantinga, Theo S., van Diemen, Cleo, Arts, Peer, Verwiel, Eugéne T.P., Gresnigt, Mark S., Fransen, Karin, van Sommeren, Suzanne, Oosting, Marije, Cheng, Shih-Chin, Joosten, Leo A.B., Hoischen, Alexander, Kullberg, Bart-Jan, Scott, William K., Perfect, John R., van der Meer, Jos W.M., Wijmenga, Cisca, Netea, Mihai G., Xavier, Ramnik J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625375/
https://ncbi.nlm.nih.gov/pubmed/23299892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2343
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