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The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the synthesis of cholesterol via the mevalonate pathway. This pathway also produces coenzyme Q (a component of the respiratory chain), dolichols (important for protein...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625262/ https://ncbi.nlm.nih.gov/pubmed/23530189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218778110 |
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