Increased Oxidative Stress Impairs Adipose Tissue Function in Sphingomyelin Synthase 1 Null Mice

Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Here, we found that SMS1 null mice showed lipodystrophic phenotype. Mutant mice showed up-regulation of plasma triglyceride concentrations accompanied by reduction of white adipose tissue (WAT) as they aged. Lipop...

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Main Authors: Yano, Masato, Yamamoto, Tadashi, Nishimura, Naotaka, Gotoh, Tomomi, Watanabe, Ken, Ikeda, Kazutaka, Garan, Yohei, Taguchi, Ryo, Node, Koichi, Okazaki, Toshiro, Oike, Yuichi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625169/
https://ncbi.nlm.nih.gov/pubmed/23593476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061380
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