Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.

The human multidrug resistance gene (MDR1) encodes a drug efflux pump glycoprotein (P-glycoprotein) responsible for resistance to multiple cytotoxic drugs. A plasmid carrying a human MDR1 cDNA under the control of a chicken beta-actin promoter was used to generate transgenic mice in which the transg...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Galski, H, Sullivan, M, Willingham, M C, Chin, K V, Gottesman, M M, Pastan, I, Merlino, G T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362516/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2573831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.10.4357-4363.1989
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