β-Adrenergic Receptor Stimulated Ncx1 Upregulation is Mediated via a CaMKII/AP-1 Signaling Pathway in Adult Cardiomyocytes

The Na(+)-Ca(2+) exchanger gene (Ncx1) is upregulated in hypertrophy and is often found elevated in end-stage heart failure. Studies have shown that the change in its expression contributes to contractile dysfunction. β-adrenergic receptor (β-AR) signaling plays an important role in the regulation o...

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Autors principals: Mani, Santhosh K., Egan, Erin A., Addy, Benjamin K., Grimm, Michael, Kasiganesan, Harinath, Thiyagarajan, Thirumagal, Renaud, Ludivine, Brown, Joan Heller, Kern, Christine B., Menick, Donald R.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624970/
https://ncbi.nlm.nih.gov/pubmed/19945464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.11.007
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