High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

We have investigated the role of the p53 gene in oncogenesis in vivo by generating transgenic mice carrying murine p53 genomic fragments isolated from a mouse Friend erythroleukemia cell line or BALB/c mouse liver DNA. Elevated levels of p53 mRNA were detected in several tissues of two transgenic li...

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書目詳細資料

發表在:	Mol Cell Biol
Principais autores:	Lavigueur, A, Maltby, V, Mock, D, Rossant, J, Pawson, T, Bernstein, A
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 1989
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362460/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2476668/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.9.3982-3991.1989
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