High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

We have investigated the role of the p53 gene in oncogenesis in vivo by generating transgenic mice carrying murine p53 genomic fragments isolated from a mouse Friend erythroleukemia cell line or BALB/c mouse liver DNA. Elevated levels of p53 mRNA were detected in several tissues of two transgenic li...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Lavigueur, A, Maltby, V, Mock, D, Rossant, J, Pawson, T, Bernstein, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362460/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2476668/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.9.3982-3991.1989
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