Adaptive Immune Responses Elicited by Baculovirus and Impacts on Subsequent Transgene Expression In Vivo

Baculovirus (BV) is a promising gene therapy vector and typically requires readministration because BV mediates transient expression. However, how the prime-boost regimen triggers BV-specific adaptive responses and their impacts on BV readministration, transgene expression, and therapeutic/vaccine e...

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Détails bibliographiques
Auteurs principaux: Luo, Wen-Yi, Lin, Shih-Yeh, Lo, Kai-Wei, Lu, Chia-Hsin, Hung, Chang-Lin, Chen, Chi-Yuan, Chang, Chien-Chung, Hu, Yu-Chen
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2013
Sujets:
Gene Delivery
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624290/
https://ncbi.nlm.nih.gov/pubmed/23408634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03510-12
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