Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex

The mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase 5 (ERK5) plays a crucial role in cell proliferation, regulating gene transcription. ERK5 has a unique C-terminal tail which contains a transcriptional activation domain, and activates transcription by phosphorylating tr...

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Main Authors: Erazo, Tatiana, Moreno, Ana, Ruiz-Babot, Gerard, Rodríguez-Asiain, Arantza, Morrice, Nicholas A., Espadamala, Josep, Bayascas, Jose R., Gómez, Nestor, Lizcano, Jose M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624243/
https://ncbi.nlm.nih.gov/pubmed/23428871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01246-12
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