Alphaherpesviral US3 Kinase Induces Cofilin Dephosphorylation To Reorganize the Actin Cytoskeleton

The conserved alphaherpesviral serine/threonine kinase US3 causes dramatic actin rearrangements, associated with increased viral spread. Here, we show that US3 of pseudorabies virus (PRV) leads to activation (dephosphorylation) of the central actin regulator cofilin. A mutation that impairs US3 kina...

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Bibliografiske detaljer
Main Authors: Jacob, Thary, Van den Broeke, Céline, van Troys, Marleen, Waterschoot, Davy, Ampe, Christophe, Favoreel, Herman W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624233/
https://ncbi.nlm.nih.gov/pubmed/23365433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03107-12
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