An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication

Dengue virus (DENV) causes dengue fever, a major health concern worldwide. We identified an amphipathic helix (AH) in the N-terminal region of the viral nonstructural protein 4A (NS4A). Disruption of its amphipathic nature using mutagenesis reduced homo-oligomerization and abolished viral replicatio...

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Detalhes bibliográficos
Main Authors: Stern, Omer, Hung, Yu-Fu, Valdau, Olga, Yaffe, Yakey, Harris, Eva, Hoffmann, Silke, Willbold, Dieter, Sklan, Ella H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624192/
https://ncbi.nlm.nih.gov/pubmed/23325687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01900-12
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