Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene e...

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Detalles Bibliográficos
Main Authors: Sims, Amy C., Tilton, Susan C., Menachery, Vineet D., Gralinski, Lisa E., Schäfer, Alexandra, Matzke, Melissa M., Webb-Robertson, Bobbie-Jo M., Chang, Jean, Luna, Maria L., Long, Casey E., Shukla, Anil K., Bankhead, Armand R., Burkett, Susan E., Zornetzer, Gregory, Tseng, Chien-Te Kent, Metz, Thomas O., Pickles, Raymond, McWeeney, Shannon, Smith, Richard D., Katze, Michael G., Waters, Katrina M., Baric, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Cellular Response to Infection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624188/
https://ncbi.nlm.nih.gov/pubmed/23365422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02520-12
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