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The BCL11A Transcription Factor Directly Activates RAG Gene Expression and V(D)J Recombination

Recombination-activating gene 1 protein (RAG1) and RAG2 are critical enzymes for initiating variable-diversity-joining (VDJ) segment recombination, an essential process for antigen receptor expression and lymphocyte development. The transcription factor BCL11A is required for B cell development, but...

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Hlavní autoři: Lee, Baeck-seung, Dekker, Joseph D., Lee, Bum-kyu, Iyer, Vishwanath R., Sleckman, Barry P., Shaffer, Arthur L., Ippolito, Gregory C., Tucker, Philip W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624176/
https://ncbi.nlm.nih.gov/pubmed/23438597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00987-12
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