Radiosynthesis and preclinical evaluation of [(11)C]prucalopride as a potential agonist PET ligand for the 5-HT(4) receptor

BACKGROUND: Serotonin 5-HT(4) receptor (5-HT(4)-R) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for treatment of constipation. The aim of this study was to develop an agonist positron emission tomography (PET) ligand in order to label the activ...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Buiter, Hans JC, Windhorst, Albert D, Huisman, Marc C, De Maeyer, Joris H, Schuurkes, Jan AJ, Lammertsma, Adriaan A, Leysen, Josée E
Format: Artigo
Langue:Inglês
Publié: Springer 2013
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623622/
https://ncbi.nlm.nih.gov/pubmed/23557209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-3-24
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