Evaluation of a Mycobacterium avium subsp. paratuberculosis leuD Mutant as a Vaccine Candidate against Challenge in a Caprine Model

Johne's disease (JD) is prevalent worldwide and has a significant impact on the global agricultural economy. In the present study, we evaluated the protective efficacy of a leuD (Δleud) mutant and gained insight into differential immune responses after challenge with virulent M. avium subsp. pa...

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Main Authors: Faisal, Syed M., Chen, Jenn-Wei, Yan, Falong, Chen, Tsai-Tzu, Useh, Nicodemus M., Yan, Weiwei, Guo, Shanguang, Wang, Shih-Jon, Glaser, Amy L., McDonough, Sean P., Singh, Bhupinder, Davis, William C., Akey, Bruce L., Chang, Yung-Fu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623397/
https://ncbi.nlm.nih.gov/pubmed/23408524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00653-12
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