Target Gene Sequencing To Define the Susceptibility of Neisseria meningitidis to Ciprofloxacin

Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥0.064 μg/ml but not among isolates with MICs of ≤0.032 μg/ml. Experimental...

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Main Authors: Hong, Eva, Thulin Hedberg, Sara, Abad, Raquel, Fazio, Cecilia, Enríquez, Rocío, Deghmane, Ala-Eddine, Jolley, Keith A., Stefanelli, Paola, Unemo, Magnus, Vazquez, Julio A., Veyrier, Frédéric J., Taha, Muhamed-Kheir
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623314/
https://ncbi.nlm.nih.gov/pubmed/23357770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02184-12
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