Target Gene Sequencing To Define the Susceptibility of Neisseria meningitidis to Ciprofloxacin

Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥0.064 μg/ml but not among isolates with MICs of ≤0.032 μg/ml. Experimental...

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Autori principali: Hong, Eva, Thulin Hedberg, Sara, Abad, Raquel, Fazio, Cecilia, Enríquez, Rocío, Deghmane, Ala-Eddine, Jolley, Keith A., Stefanelli, Paola, Unemo, Magnus, Vazquez, Julio A., Veyrier, Frédéric J., Taha, Muhamed-Kheir
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623314/
https://ncbi.nlm.nih.gov/pubmed/23357770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02184-12
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