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Identification of a Cyclosporine-Specific P450 Hydroxylase Gene through Targeted Cytochrome P450 Complement (CYPome) Disruption in Sebekia benihana

It was previously proposed that regio-specific hydroxylation of an immunosuppressive cyclosporine (CsA) at the 4th N-methyl leucine is mediated by cytochrome P450 hydroxylase (CYP) in the rare actinomycete Sebekia benihana. This modification is thought to be the reason for the hair growth-promoting...

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מידע ביבליוגרפי
Main Authors: Lee, Mi-Jin, Kim, Hyun-Bum, Yoon, Yeo Joon, Han, Kyuboem, Kim, Eung-Soo
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623247/
https://ncbi.nlm.nih.gov/pubmed/23354713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03722-12
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