Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study

BACKGROUND: Given that memantine is thought to decrease N-methyl-D-aspartic-acid-related (NMDA) glutamatergic hyperactivity and improve locomotion in rats, we sought to assess the drug's impact on axial symptoms in advanced Parkinson's disease (PD). METHODS: We performed a 90-day, randomis...

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Detalhes bibliográficos
Main Authors: Moreau, Caroline, Delval, Arnaud, Tiffreau, Vincent, Defebvre, Luc, Dujardin, Kathy, Duhamel, Alain, Petyt, Gregory, Hossein-Foucher, Claude, Blum, David, Sablonnière, Bernard, Schraen, Susanna, Allorge, Delphine, Destée, Alain, Bordet, Régis, Devos, David
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2013
Assuntos:
Movement Disorders
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623038/
https://ncbi.nlm.nih.gov/pubmed/23077087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2012-303182
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