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Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene.

The 5'-flanking region of the rat insulin II gene (-448 to +50) is sufficient for tissue-specific expression. To further determine the tissue-specific cis-acting element(s), important sequences defined by linker-scanning mutagenesis were placed upstream of a heterologous promoter and transfecte...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Hwung, Y P, Gu, Y Z, Tsai, M J
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1990
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362286/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2181285/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.4.1784
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