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Spinal Toll-like receptor signaling and nociceptive processing: Regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ

Toll-like Receptors (TLRs) play a pivotal role in inflammatory processes and individual TLRs have been investigated in nociception. Here, we examine overlapping and diverging roles of spinal TLRs and their associated adaptor proteins in nociceptive processing. Intrathecal (IT) TLR2, TLR3, or TLR4 li...

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Main Authors: Stokes, Jennifer A., Corr, Maripat, Yaksh, Tony L.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622773/
https://ncbi.nlm.nih.gov/pubmed/23489833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.01.012
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