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Spinal Toll-like receptor signaling and nociceptive processing: Regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ

Toll-like Receptors (TLRs) play a pivotal role in inflammatory processes and individual TLRs have been investigated in nociception. Here, we examine overlapping and diverging roles of spinal TLRs and their associated adaptor proteins in nociceptive processing. Intrathecal (IT) TLR2, TLR3, or TLR4 li...

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Detalhes bibliográficos
Main Authors: Stokes, Jennifer A., Corr, Maripat, Yaksh, Tony L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622773/
https://ncbi.nlm.nih.gov/pubmed/23489833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.01.012
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