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Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles

BACKGROUND: Identification of gene-phenotype relationships is a fundamental challenge in human health clinic. Based on the observation that genes causing the same or similar phenotypes tend to correlate with each other in the protein-protein interaction network, a lot of network-based approaches wer...

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Autors principals: Zhu, Jie, Qin, Yufang, Liu, Taigang, Wang, Jun, Zheng, Xiaoqi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622672/
https://ncbi.nlm.nih.gov/pubmed/23734762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-14-S5-S5
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