Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells

Here, antitumor mechanism of cinnamaldehyde derivative CB-PIC was elucidated in human SW620 colon cancer cells. CB-PIC significantly exerted cytotoxicity, increased sub-G1 accumulation, and cleaved PARP with apoptotic features, while it enhanced the phosphorylation of AMPK alpha and ACC as well as a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Cho, Sung-Yun, Lee, Hyo-Jeong, Lee, Hyo-Jung, Jung, Deok-Beom, Kim, Hyunseok, Sohn, Eun Jung, Kim, Bonglee, Jung, Ji Hoon, Kwon, Byoung-Mog, Kim, Sung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622407/
https://ncbi.nlm.nih.gov/pubmed/23589723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/974313
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados