Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells

Although cryptotanshinone (CT) was known to exert antitumor activity in several cancers, its molecular mechanism under hypoxia still remains unclear. Here, the roles of AEG-1 and HIF-1α in CT-induced antitumor activity were investigated in hypoxic PC-3 cells. CT exerted cytotoxicity against prostate...

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Detalhes bibliográficos
Main Authors: Lee, Hyo-Jeong, Jung, Deok-Beom, Sohn, Eun Jung, Kim, Hanna Hyun, Park, Moon Nyeo, Lew, Jae-Hwan, Lee, Seok Geun, Kim, Bonglee, Kim, Sung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519236/
https://ncbi.nlm.nih.gov/pubmed/23243443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/390957
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