Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms

Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis. To search for corresponding differences in leukotriene biosynthesis, we screened the Neandertal genome for LOX g...

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Bibliografiske detaljer
Main Authors: Chaitidis, Pavlos, Adel, Susan, Anton, Monika, Heydeck, Dagmar, Kuhn, Hartmut, Horn, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622333/
https://ncbi.nlm.nih.gov/pubmed/23475662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M035626
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