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Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease
The Akt signaling pathway controls several cellular functions in the cardiovascular system; however, its role in atherogenesis is unknown. Here we show that the genetic ablation of Akt1 on an apolipoprotein E knockout background (ApoE(−/−)Akt1(−/−)) increases aortic lesion expansion and promotes cor...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3621848/ https://ncbi.nlm.nih.gov/pubmed/18054314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.10.007 |
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