Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15

Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15) causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1). Indeed, the disruption of this association restores insulin sensitivity in cultured cells over-expressing...

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Main Authors: Cassese, Angela, Raciti, Gregory A., Fiory, Francesca, Nigro, Cecilia, Ulianich, Luca, Castanò, Ilenia, D’Esposito, Vittoria, Terracciano, Daniela, Pastore, Lucio, Formisano, Pietro, Beguinot, Francesco, Miele, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621763/
https://ncbi.nlm.nih.gov/pubmed/23585839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060555
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