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Redox-responsive Zinc Finger Fidelity Switch in Homing Endonuclease and Intron Promiscuity in Oxidative Stress

Mobile introns home to allelic sites, but how they are stimulated to invade ectopic locations on an evolutionary time-scale is unclear [1]. Here we show that a group I intron can move to degenerate sites under oxidizing conditions. The phage T4 td intron endonuclease, I-TevI is responsible for this...

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Bibliographic Details
Main Authors: Robbins, Justin B., Smith, Dorie, Belfort, Marlene
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621118/
https://ncbi.nlm.nih.gov/pubmed/21256016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.01.008
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