Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6

Background: Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially more toxic than the parent PBDEs. However, the...

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Bibliographische Detailangaben
Hauptverfasser: Feo, Maria Luisa, Gross, Michael S., McGarrigle, Barbara P., Eljarrat, Ethel, Barceló, Damià, Aga, Diana S., Olson, James R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Institute of Environmental Health Sciences 2012
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620761/
https://ncbi.nlm.nih.gov/pubmed/23249762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1205446
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