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An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways

Epigenetic changes have been associated with ageing and cancer. Identifying and interpreting epigenetic changes associated with such phenotypes may benefit from integration with protein interactome models. We here develop and validate a novel integrative epigenome-interactome approach to identify di...

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Autori principali: West, James, Beck, Stephan, Wang, Xiangdong, Teschendorff, Andrew E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620664/
https://ncbi.nlm.nih.gov/pubmed/23568264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01630
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