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An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways

Epigenetic changes have been associated with ageing and cancer. Identifying and interpreting epigenetic changes associated with such phenotypes may benefit from integration with protein interactome models. We here develop and validate a novel integrative epigenome-interactome approach to identify di...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: West, James, Beck, Stephan, Wang, Xiangdong, Teschendorff, Andrew E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620664/
https://ncbi.nlm.nih.gov/pubmed/23568264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01630
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