Maternal antioxidants prevent beta cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure

AIM: Fetal and neonatal nicotine exposure causes beta cell oxidative stress and apoptosis in neonates, leading to adult-onset dysglycemia. The goal of this study was to determine whether an antioxidant intervention could prevent nicotine-induced beta cell loss. METHODS: Nulliparous female Wistar rat...

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Autores principales: BRUIN, Jennifer E, WOYNILLOWICZ, Amanda K, HETTINGA, Bart P, TARNOPOLSKY, Mark A, MORRISON, Katherine M, GERSTEIN, Hertzel C, HOLLOWAY, Alison C
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620564/
https://ncbi.nlm.nih.gov/pubmed/22385833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1753-0407.2012.00195.x
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