PGE(2) Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway

The polarization of macrophages into a regulatory-like phenotype and the production of IL-10 plays an important role in the resolution of inflammation. We show in this study that PGE(2), in combination with LPS, is able to promote an anti-inflammatory phenotype in macrophages characterized by high e...

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Detalhes bibliográficos
Main Authors: MacKenzie, Kirsty F., Clark, Kristopher, Naqvi, Shaista, McGuire, Victoria A., Nöehren, Gesa, Kristariyanto, Yosua, van den Bosch, Mirjam, Mudaliar, Manikhandan, McCarthy, Pierre C., Pattison, Michael J., Pedrioli, Patrick G. A., Barton, Geoff J., Toth, Rachel, Prescott, Alan, Arthur, J. Simon C.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2013
Assuntos:
Immune Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620524/
https://ncbi.nlm.nih.gov/pubmed/23241891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202462
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