Carbon Monoxide Abrogates Ischemic Insult to Neuronal Cells via the Soluble Guanylate Cyclase-cGMP Pathway

PURPOSE: Carbon monoxide (CO) is an accepted cytoprotective molecule. The extent and mechanisms of protection in neuronal systems have not been well studied. We hypothesized that delivery of CO via a novel releasing molecule (CORM) would impart neuroprotection in vivo against ischemia-reperfusion in...

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Detalhes bibliográficos
Main Authors: Schallner, Nils, Romão, Carlos C., Biermann, Julia, Lagrèze, Wolf A., Otterbein, Leo E., Buerkle, Hartmut, Loop, Torsten, Goebel, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620383/
https://ncbi.nlm.nih.gov/pubmed/23593279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060672
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