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Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies
In PML/RARA-driven acute promyelocytic leukemia (APL), retinoic acid (RA) induces leukemia cell differentiation and transiently clears the disease. Molecularly, RA activates PML/RARA-dependent transcription and also initiates its proteasome-mediated degradation. In contrast, arsenic, the other poten...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3620357/ https://ncbi.nlm.nih.gov/pubmed/23509325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122337 |
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