Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization

The pathogenesis of acute promyelocytic leukemia involves the transcriptional repression of master genes of myeloid differentiation by the promyelocytic leukemia–retinoic acid receptor α (PML/RARA) oncogene. PML-enforced RARA homodimerization allows the tighter binding of corepressors, silencing RAR...

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Hauptverfasser: Zhou, Jun, Pérès, Laurent, Honoré, Nicole, Nasr, Rihab, Zhu, Jun, de Thé, Hugues
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474145/
https://ncbi.nlm.nih.gov/pubmed/16757557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603324103
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