Co-delivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticle to Overcome Drug Resistance in Breast Cancer In Vitro and In Vivo

We used a multi-functional mesoporous silica nanoparticle (MSNP) carrier to overcome doxorubicin (Dox) resistance in a multidrug resistant (MDR) human breast cancer xenograft by co-delivering Dox and siRNA that targets the P-glycoprotein (Pgp) drug exporter. The Pgp siRNA selection from among a seri...

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Detalhes bibliográficos
Main Authors: Meng, Huan, Mai, Wilson X., Zhang, Haiyuan, Xue, Min, Xia, Tian, Lin, Sijie, Wang, Xiang, Zhao, Yang, Ji, Zhaoxia, Zink, Jeffrey I., Nel, Andre E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620006/
https://ncbi.nlm.nih.gov/pubmed/23289892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn3044066
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