Myoglobin-H(2)O(2) catalyzes the oxidation of β-ketoacids to α-dicarbonyls: mechanism and implications in ketosis

Acetoacetate (AA) and 2-methylacetoacetate (MAA) are accumulated in metabolic disorders such as diabetes and isoleucinemia. Here we examine the mechanism of AA and MAA aerobic oxidation initiated by myoglobin (Mb)/H(2)O(2). We propose a chemiluminescent route involving a dioxetanone intermediate who...

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Autori principali: Ganini, Douglas, Christoff, Marcelo, Ehrenshaft, Marilyn, Kadiiska, Maria B, Mason, Ronald P, Bechara, Etelvino JH
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619417/
https://ncbi.nlm.nih.gov/pubmed/21609760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.05.002
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