Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1

Decreased cerebral blood flow (CBF) may contribute to the pathology of multiple sclerosis (MS), but the underlying mechanism is unknown. We investigated whether the potent vasoconstrictor endothelin-1 (ET-1) is involved. We found that, compared with controls, plasma ET-1 levels in patients with MS w...

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Autori principali: D’haeseleer, Miguel, Beelen, Roel, Fierens, Yves, Cambron, Melissa, Vanbinst, Anne-Marie, Verborgh, Christian, Demey, Johan, De Keyser, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619305/
https://ncbi.nlm.nih.gov/pubmed/23509249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222560110
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