Whole-genome haplotyping by dilution, amplification, and sequencing

Standard whole-genome genotyping technologies are unable to determine haplotypes. Here we describe a method for rapid and cost-effective long-range haplotyping. Genomic DNA is diluted and distributed into multiple aliquots such that each aliquot receives a fraction of a haploid copy. The DNA templat...

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Detalhes bibliográficos
Main Authors: Kaper, Fiona, Swamy, Sajani, Klotzle, Brandy, Munchel, Sarah, Cottrell, Joseph, Bibikova, Marina, Chuang, Han-Yu, Kruglyak, Semyon, Ronaghi, Mostafa, Eberle, Michael A., Fan, Jian-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619281/
https://ncbi.nlm.nih.gov/pubmed/23509297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218696110
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