Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer

BACKGROUND: Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those fo...

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Main Authors: De Faveri, L E, Hurst, C D, Platt, F M, Taylor, C F, Roulson, J-A, Sanchez-Carbayo, M, Knowles, M A, Chapman, E J
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2013
主題:
Genetics & Genomics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619261/
https://ncbi.nlm.nih.gov/pubmed/23549060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.104
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