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Catalytic Efficiency of Enzymes: A Theoretical Analysis
This brief review analyzes the underlying physical principles of enzyme catalysis, with an emphasis on the role of equilibrium enzyme motions and conformational sampling. The concepts are developed in the context of three representative systems, namely dihydrofolate reductase, ketosteroid isomerase,...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3619019/ https://ncbi.nlm.nih.gov/pubmed/23240765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301515j |
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