Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via In Situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

Nicotinic acetylcholine receptors (nAChRs), being responsible for mediating key physiological functions, are ubiquitous in the central and peripheral nervous systems. As members of the Cys loop ligand-gated ion channel family, neuronal nA-ChRs are pentameric, composed of various permutations of α (α...

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Main Authors: Grimster, Neil P., Stump, Bernhard, Fotsing, Joseph R., Weide, Timo, Talley, Todd T., Yamauchi, John G., Nemecz, Ákos, Kim, Choel, Ho, Kwok-Yiu, Sharpless, K. Barry, Taylor, Palmer, Fokin, Valery V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618991/
https://ncbi.nlm.nih.gov/pubmed/22394239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3001858
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