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Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via In Situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
Nicotinic acetylcholine receptors (nAChRs), being responsible for mediating key physiological functions, are ubiquitous in the central and peripheral nervous systems. As members of the Cys loop ligand-gated ion channel family, neuronal nA-ChRs are pentameric, composed of various permutations of α (α...
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主要な著者: | , , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2012
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3618991/ https://ncbi.nlm.nih.gov/pubmed/22394239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3001858 |
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