Brain extracellular γ-hydroxybutyrate concentrations are decreased by L-lactate in rats: Role in the treatment of overdoses

PURPOSE: L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by monocarboxylate transporters. Our objective was to assess the dose-dependence of L-lactate treatment, with and without D-mannitol, on GHB toxicokinetics/toxicodynamics (TK/TD). METHO...

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Main Authors: Roiko, Samuel A., Vijay, Nisha, Felmlee, Melanie A., Morris, Marilyn E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618608/
https://ncbi.nlm.nih.gov/pubmed/23319173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-0973-z
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