Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

To understand why cancer vaccine-induced T cells often fail to eradicate tumors, we studied immune responses in mice vaccinated with gp100 melanoma peptide in incomplete Freund’s adjuvant (IFA), commonly used in clinical cancer vaccine trials. Peptide/IFA vaccination primed tumor-specific CD8(+) T c...

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Detalhes bibliográficos
Main Authors: Hailemichael, Yared, Dai, Zhimin, Jaffarzad, Nina, Ye, Yang, Medina, Miguel A, Huang, Xue-Fei, Dorta-Estremera, Stephanie M, Greeley, Nathaniel R, Nitti, Giovanni, Peng, Weiyi, Liu, Chengwen, Lou, Yanyan, Wang, Zhiqiang, Ma, Wencai, Rabinovich, Brian, Schluns, Kimberly S, Davis, Richard E, Hwu, Patrick, Overwijk, Willem W
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618499/
https://ncbi.nlm.nih.gov/pubmed/23455713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3105
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