Mechanisms of Topoisomerase I (TOP1) Gene Copy Number Increase in a Stage III Colorectal Cancer Patient Cohort

BACKGROUND: Topoisomerase I (Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at elevated copy numbers in colorectal cancer (CRC). The present study explores the mechanism, frequency and prognostic impact of TOP1 gene aberrations in st...

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Autors principals: Smith, David Hersi, Christensen, Ib Jarle, Jensen, Niels Frank, Markussen, Bo, Rømer, Maria Unni, Nygård, Sune Boris, Müller, Sven, Nielsen, Hans Jørgen, Brünner, Nils, Nielsen, Kirsten Vang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618421/
https://ncbi.nlm.nih.gov/pubmed/23577133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060613
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