Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal

Phenelzine (PZ) is a scavenger of the lipid peroxidation (LP)-derived reactive aldehyde 4-hydroxynonenal (4-HNE) due to its hydrazine functional group, which can covalently react with 4-HNE. In this study, we first examined the ability of PZ to prevent the respiratory depressant effects of 4-HNE on...

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Bibliographic Details
Main Authors: Singh, Indrapal N, Gilmer, Lesley K, Miller, Darren M, Cebak, John E, Wang, Juan A, Hall, Edward D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618398/
https://ncbi.nlm.nih.gov/pubmed/23321786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.211
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